Friday, November 9, 2012

A Primer On Risks From AI

Alexander Kruel

November 9, 2012

The Power of Algorithms

Evolutionary processes are the most evident example of the power of simple algorithms.[1][2][3][4][5]

The field of evolutionary biology gathered a vast amount of evidence [6] that established evolution as the process that explains the local decrease in entropy[7], the complexity of life.

Since it can be conclusively shown that all life is an effect of an evolutionary process it is implicit that everything we do not understand about living beings is also an effect of evolution.

We might not understand the nature of intelligence[8] and consciousness[9] but we do know that they are the result of an optimization process that is neither intelligent nor conscious.

Therefore we know that it is possible for an physical optimization process to culminate in the creation of more advanced processes that feature superior qualities.

One of these qualities is the human ability to observe and improve the optimization process that created us. The most obvious example being science.[10]

Science can be thought of as civilization-level self-improvement method. It allows us to work together in a systematic and efficient way and accelerate the rate at which further improvements are made.

The Automation of Science

We know that optimization processes that can create improved versions of themselves are possible, even without an explicit understanding of their own workings, as exemplified by natural selection.

We know that optimization processes can lead to self-reinforcing improvements, as exemplified by the adaptation of the scientific method[11] as an improved evolutionary process and successor of natural selection.

Which raises questions about the continuation of this self-reinforcing feedback cycle and its possible implications.

One possibility is to automate science[12][13] and apply it to itself and its improvement.

But science is a tool and its bottleneck are its users. Humans, the biased[14] effect of the blind idiot god that is evolution.

Therefore the next logical step is to use science to figure out how to replace humans by a better version of themselves, artificial general intelligence.

Artificial general intelligence, that can recursively optimize itself [15], is the logical endpoint of various converging and self-reinforcing feedback cycles.

Risks from AI

Will we be able to build an artificial general intelligence? Yes, sooner or later.

Even the unintelligent, unconscious and aimless process of natural selection was capable of creating goal-oriented, intelligent and conscious agents that can think ahead, jump fitness gaps and improve upon the process that created them to engage in prediction and direct experimentation.

The question is, what are the possible implications of the invention of an artificial, fully autonomous, intelligent and goal-oriented optimization process?

One good bet is that such an agent will recursively improve its most versatile, and therefore instrumentally useful, resource. It will improve its general intelligence, respectively cross-domain optimization power.

Since it is unlikely that human intelligence is the optimum, the positive feedback effect, that is a result of using intelligence amplifications to amplify intelligence, is likely to lead to a level of intelligence that is generally more capable than the human intelligence level.

Humans are unlikely to be the most efficient thinkers because evolution is mindless and has no goals. Evolution did not actively try to create the smartest thing possible.

Evolution is further not limitlessly creative, each step of an evolutionary design must increase the fitness of its host. Which makes it probable that there are artificial mind designs that can do what no product of natural selection could accomplish, since an intelligent artificer does not rely on the incremental fitness of each step in the development process.

It is actually possible that human general intelligence is the bare minimum. Because the human level of intelligence might have been sufficient to both survive and reproduce and that therefore no further evolutionary pressure existed to select for even higher levels of general intelligence.

The implications of this possibility might be the creation of an intelligent agent that is more capable than humans in every sense. Maybe because it does directly employ superior approximations of our best formal methods, that tell us how to update based on evidence and how to choose between various actions. Or maybe it will simply think faster. It doesn?t matter.

What matters is that a superior intellect is probable and that it will be better than us at discovering knowledge and inventing new technology. Technology that will make it even more powerful and likely invincible.

And that is the problem. We might be unable to control such a superior being. Just like a group of chimpanzees is unable to stop a company from clearing its forest.[16]

But even if such a being is only slightly more capable than us. We might find ourselves at its mercy nonetheless.

Human history provides us with many examples[17][18][19] that make it abundantly clear that even the slightest advance can enable one group to dominate others.

What happens is that the dominant group imposes its values on the others. Which in turn raises the question of what values an artificial general intelligence might have and the implications of those values for us.

Due to our evolutionary origins, our struggle for survival and the necessity to cooperate with other agents, we are equipped with many values and a concern for the welfare of others.[20]

The information theoretic complexity[21][22] of our values is very high. Which means that it is highly unlikely for similar values to automatically arise in agents that are the product of intelligent design, agents that never underwent the million of years of competition with other agents that equipped humans with altruism and general compassion.

But that does not mean that an artificial intelligence won?t have any goals.[23][24] Just that those goals will be simple and their realization remorseless.[25]

An artificial general intelligence will do whatever is implied by its initial design. And we will be helpless to stop it from achieving its goals. Goals that won?t automatically respect our values.[26]

A likely implication is the total extinction of all of humanity.[27][28]

Further Reading

References

[1] Genetic Algorithms and Evolutionary Computation, talkorigins.org/faqs/genalg/genalg.html
[2] Fixing software bugs in 10 minutes or less using evolutionary computation, genetic-programming.org/hc2009/1-Forrest/Forrest-Presentation.pdf
[3] Automatically Finding Patches Using Genetic Programming, genetic-programming.org/hc2009/1-Forrest/Forrest-Paper-on-Patches.pdf
[4] A Genetic Programming Approach to Automated Software Repair, genetic-programming.org/hc2009/1-Forrest/Forrest-Paper-on-Repair.pdf
[5]GenProg: A Generic Method for Automatic Software Repair, virginia.edu/~weimer/p/weimer-tse2012-genprog.pdf
[6] 29+ Evidences for Macroevolution (The Scientific Case for Common Descent), talkorigins.org/faqs/comdesc/
[7] Thermodynamics, Evolution and Creationism, talkorigins.org/faqs/thermo.html
[8] A Collection of Definitions of Intelligence, vetta.org/documents/A-Collection-of-Definitions-of-Intelligence.pdf
[9] plato.stanford.edu/entries/consciousness/
[10] en.wikipedia.org/wiki/Science
[11] en.wikipedia.org/wiki/Scientific_method
[12] The Automation of Science, sciencemag.org/content/324/5923/85.abstract
[13] Computer Program Self-Discovers Laws of Physics, wired.com/wiredscience/2009/04/newtonai/
[14] List of cognitive biases, en.wikipedia.org/wiki/List_of_cognitive_biases
[15] Intelligence explosion, wiki.lesswrong.com/wiki/Intelligence_explosion
[16] 1% with Neil deGrasse Tyson, youtu.be/9nR9XEqrCvw
[17] Mongol military tactics and organization, en.wikipedia.org/wiki/Mongol_military_tactics_and_organization
[18] Wars of Alexander the Great, en.wikipedia.org/wiki/Wars_of_Alexander_the_Great
[19] Spanish colonization of the Americas, en.wikipedia.org/wiki/Spanish_colonization_of_the_Americas
[20] A Quantitative Test of Hamilton?s Rule for the Evolution of Altruism, plosbiology.org/article/info:doi/10.1371/journal.pbio.1000615
[21] Algorithmic information theory, scholarpedia.org/article/Algorithmic_information_theory
[22] Algorithmic probability, scholarpedia.org/article/Algorithmic_probability
[23] The Nature of Self-Improving Arti?cial Intelligence, selfawaresystems.files.wordpress.com/2008/01/nature_of_self_improving_ai.pdf
[24] The Basic AI Drives, selfawaresystems.files.wordpress.com/2008/01/ai_drives_final.pdf
[25] Paperclip maximizer, wiki.lesswrong.com/wiki/Paperclip_maximizer
[26] Friendly artificial intelligence, wiki.lesswrong.com/wiki/Friendly_artificial_intelligence
[27] Existential Risk, existential-risk.org
[28] 5 minutes on AI risk youtu.be/3jSMe0owGMs

Source: http://hplusmagazine.com/2012/11/09/a-primer-on-risks-from-ai/

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Is that Chris Brown in Rihanna's new video?

By Bruna Nessif, E! Online

Another video full of complex imagery and storytelling--or in any case, Rihanna being all mysterious and sexy--has been released for your viewing pleasure.

The Barbadian beauty released her music video for the first single of her "Unapologetic" album, "Diamonds," which begins with a black-and-white visual of the singer rolling, um, something, with diamonds.

Not sure how that would work, but we'll go with it.

Rihanna and Chris Brown tease new song together

In between moments of exhaling a certain type of smoke (ahem), fans see Ri-Ri at various locations that highlight one of the elements: earth, wind, water and fire.

There's also a couple of scenes that show her hand slowly releasing the grasp of a male's tattooed arm, which may or may not be?a surprise guest appearance by none other than Chris Brown. It's not a farfetched thought.

Watch the official video for "Diamonds" and let us know what you think in the comments below!

Fashion Spotlight: Rihanna

Evan Agostini / AP

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Source: http://entertainment.nbcnews.com/_news/2012/11/09/15050606-rihanna-debuts-diamonds-video-is-that-chris-brown?lite

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Thursday, November 8, 2012

New cells found that could help save people's sight

ScienceDaily (Nov. 8, 2012) ? Eye experts and scientists at the University of Southampton have discovered specific cells in the eye which could lead to a new procedure to treat and cure blinding eye conditions.

Led by Professor Andrew Lotery, the study found that cells called corneal limbal stromal cells, taken from the front surface of the eye have stem cell properties and could be cultured to create retinal cells.

This could lead to new treatments for eye conditions such as retinitis pigmentosa or wet age-related macular degeneration, a condition which is a common cause of loss of vision in older people and will affect around one in three people in the UK by age 70.

Furthermore the research, published in the British Journal for Ophthalmology, suggests that using corneal limbus cells would be beneficial in humans as it would avoid complications with rejection or contamination because the cells taken from the eye would be returned to the same patient.

Professor Lotery, who is also a Consultant Ophthalmologist at Southampton General Hospital, comments: "This is an important step for our research into the prevention and treatment of eye conditions and blindness.

"We were able to characterize the corneal limbal stromal cells found on the front surface of the eye and identify the precise layer in the cornea that they came from. We were then successful in culturing them in a dish to take on some of the properties of retinal cells. We are now investigating whether these cells could be taken from the front of the eye and be used to replace diseased cells in the back of the eye in the retina. If successful this would open up new and efficient ways of treating people who have blinding eye conditions."

This is a promising discovery as the corneal limbus is one of the most accessible regions of the human eye and it represents 90 per cent of the thickness of the front eye wall. Therefore cells could be easily obtainable from this area with little risk to the patient's eye and sight. However Professor Lotery says more research is needed to develop this approach before they are used in patients.

The research was funded by the National Eye Research Centre, Gift of Sight and Rosetree Trust.

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Story Source:

The above story is reprinted from materials provided by University of Southampton.

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Journal Reference:

  1. X. Chen, H. Thomson, P. Hossain, A. Lotery. Characterisation of mouse limbal neurosphere cells: a potential cell source of functional neurons. British Journal of Ophthalmology, 2012; 96 (11): 1431 DOI: 10.1136/bjophthalmol-2012-301546

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/06UDF8ICJiY/121108104311.htm

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Bora ZivkovicAbout the Author: Bora Zivkovic is the Blog Editor at Scientific American, chronobiologist, biology teacher, organizer of ScienceOnline conferences and editor of Open Laboratory anthologies of best science writing on the Web. Follow on Twitter @boraz.

The views expressed are those of the author and are not necessarily those of Scientific American.

Source: http://rss.sciam.com/click.phdo?i=e452565a0a828ecea7dc3bb695f8711b

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Wednesday, November 7, 2012

Head-to-head trial of two diabetes drugs yields mixed results

ScienceDaily (Nov. 6, 2012) ? A direct, head-to-head comparison of two of the newer treatments available for type 2 diabetes yielded mixed results.

The 26-week, multicenter DURATION-6 clinical trial found that daily injections of liraglutide (Victoza) were slightly more effective than weekly injections of exenatide (Bydureon) in lowering blood sugar and promoting weight loss in patients with type 2 diabetes. However, the patients taking exenatide suffered fewer negative side effects such as nausea, diarrhea and vomiting.

"Both of these agents are very exciting diabetes products and really good blood sugar-lowering drugs," said John B. Buse, MD, PhD, first author of the study, division chief of endocrinology and metabolism in the University of North Carolina School of Medicine, director of the UNC Diabetes Care Center and a a PI Extender of the UNC NIH Clinical and Translational Science Awards (CTSA).

"The results of this study will be helpful to both doctors and patients in shared decision-making about which of these two drugs is better suited for a particular patient," Buse said. "For example, for some patients the additional weight loss advantage provided by liraglutide might tip the scales in favor of that drug. For other patients, though, the greater convenience of once-weekly injections and the more favorable side effects profile of exenatide would be extremely appealing."

Results of the study were published online ahead of print on Nov. 7, 2012 by The Lancet.

In the study, 912 patients from 105 sites in 19 countries were randomized to receive injections of once-daily liraglutide or once-weekly exenatide for 26 weeks. The primary endpoint of the study was the overall reduction in HbA1c (blood sugar) levels from baseline to 26 weeks.

Both drugs produced a clinically significant decrease in blood sugar levels. By the end of the study, 60 percent of the patients taking liraglutide had achieved HbA1c levels of less than 7 percent, vs. 53 percent of patients on exenatide. Both drugs also produced progressive decreases in bodyweight, but patients taking liraglutide lost about 2 pounds more weight than those on exenatide.

Patients in both groups reported having side effects on occasions over the six month trial. The most common were nausea (21 percent in the liraglutide group vs. 9 percent in the exenatide group), diarrhea (13 percent vs. 6 percent) and vomiting (11 percent vs. 4 percent). The occurrence of side effects lessened in both groups over time. Five percent of patients on liraglutide and 3 percent on exenatide dropped out of the study because of side effects.

The study was funded by Eli Lilly and Amylin Pharmaceuticals. Amylin is the manufacturer of Bydureon, the exenatide preparation that was used in this study.

In addition to Dr. Buse, other authors were Michael Nauck, Thomas Forst, Wayne H-H Sheu, Sylvia K. Shenouda, Cory R. Heilmann, Byron J. Hoogwerf, Aijun Gao, Marilyn K. Boardman, Mark Fineman, Lisa Porter and Guntram Schemthaner.

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Story Source:

The above story is reprinted from materials provided by University of North Carolina School of Medicine.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. John B Buse et al. Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomised, open-label study. The Lancet, 7 November 2012 DOI: 10.1016/S0140-6736(12)61267-7

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/Zvj2Yak1GG0/121106201036.htm

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